White-tailed Deer sign in the southern most part of The Colony, Texas
Here is what Wikipedia has to say about White-tailed Deer:
There are several natural predators of white-tailed deer. Wolves, cougars, American alligators, and (in the tropics) jaguars are the more effective natural predators of white-tailed deer. These predators frequently pick out easily caught young or infirm deer (which is believed to incidentally improve the genetic stock of a population) but can and do take healthy adults of any size. Bobcats, lynxes, bears, wolverines, and packs of coyotes usually will prey mainly on deer fawns. Bears may sometimes attack adult deer while lynxes, coyotes, wolverines and bobcats are most likely to take adult deer when the ungulates are weakened by harsh winter weather. Many scavengers rely on deer as carrion, including New World vultures, raptors, foxes, and corvids. Few wild predators can afford to be picky and any will readily consume deer as carrion. There are records of American Crows attempting to predate white-tailed deer fawns by pecking around their face and eyes, though there are no accounts of successful predation. Occasionally, both Golden and Bald Eagles may capture deer fawns with their talons. In one case, a Golden Eagle was filmed in Illinois unsuccessfully trying to predate a large mature white-tailed deer.